The school district offers 38 Advanced Placement Courses and several Career and Technical Education programs for a variety of career clusters.

Several Lake County high schools offer the AP Capstone Diploma Program, a College Board program that equips students with skills in independent research, collaborative teamwork and communication.

Dual Enrollment opportunities are available with the University of Florida, Lake Technical College, Lake-Sumter State College and Embry-Riddle Aeronautical University.

Students enrolled in the Career & Professional CAPE Academy receive hands-on training in workplace settings using industry-standard equipment, and upon graduation have received the training required for an entry-level position in their career field.

The Health Sciences Collegiate Academy (HSCA) is an accelerated academic program that offers students the opportunity to explore careers in the STEM and health sciences through hands-on activities and early exposure to college courses.

The Cambridge Advanced International Certificate of Education (AICE) Diploma is an international curriculum that provides students the opportunity to master a broad range of critical skills for success in university study and employment.

Advancement Via Individual Determination (AVID), a college and career readiness system, is offered to all Lake County middle and high school students. The program teaches students important soft skills such as writing-to-learn, inquiry, collaboration, organizational skills and critical reading.